Therapeutic failure or resistance to aspirin

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Therapeutic Failure or Resistance to Aspirin

1. Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002;288:2411–20. 2. Mehta SR, Yusuf S, Peters RJG, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE st...

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Therapeutic failure or resistance to aspirin.

1. Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002;288:2411–20. 2. Mehta SR, Yusuf S, Peters RJG, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE st...

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The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?

Introduction Cyclooxygenase-1 [COX-1, prostaglandin synthase] catalyses the transformation of arachidonic acid to the unstable intermediate prostaglandin PGH2. Subsequently, thromboxane synthase acts on PGH2 to form TXA2, a transient biological product that induces platelet aggregation and is a powerful vasoconstrictor. Aspirin acts primarily by interfering with the biosynthesis of cyclic prost...

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Hypotensive response after resistance exercise leading to failure and not to failure in trained men

Hypertension is epidemic disease which post-exercise hypotension (PEH) is useful strategies for hypertension. The aim of present study was to investigate the effects of resistance exercise leading to failure (REF) and resistance exercise not to failure (NREF) on PEH phenomenon in trained men. Eight trained men (age: 22.12±1.81 yr; height: 179±3.44 cm; weight: 73.82±4.29 kg;...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2004

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2004.01.011